Neuroimmune guidance cues for vascular health

Author(s):
Zhang, H.
Published
2021
Publication type
Doctoral Thesis

Abstract

This thesis aimed to provide evidence that supports a central role for NGCs in CVD by studying the expression, regulation and function of neuronal guidance cues (NGCs) in endothelial cells and monocytes, the 2 cells types that play main role in development of atherosclerosis. The findings laid the foundation for future research of NGCs as novel tar- gets for intervention of atherosclerosis.

Neuronal guidance cues (NGCs)Endothelial cell biologyMonocyte biologyAtherosclerosisQuakingPost-transcriptional regulationPrediction modelling
Defense date
2021-06-01
Language
English
Supervisor(s)
Zonneveld, A.J. van
Advisor(s)
Gils, J.M. van
Committee member(s)
Kooten, C. van; Jongbloed, M.R.M.; Wang, Y.; Hordijk, P.; Vries, C. de
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/3176518

Funding

Sponsorship
The studies in this thesis were carried out at the Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, the Netherlands. The research was supported by a grant from the Netherlands Heart Foundation (2013T127).