The iron brain: Post-mortem and in vivo imaging of iron in brain diseases

Author(s):
Bulk, M.
Published
2021
Publication type
Doctoral Thesis

Abstract

This thesis aimed to gain more insight into the role of iron in neurodegenerative diseases using high-field MRI. I investigated the pathological correlates of susceptibility-based contrasts on MRI, and how iron accumulation is associated with disease progression both ex vivo and in vivo.

MRIIronQuantitative susceptibility mappingAlzheimer's diseaseNeuroinflammationMyelinProtein aggregation
Defense date
2021-03-03
Language
English
Supervisor(s)
Buchem, M.A. van
Advisor(s)
Ronen, I.; Weerd, L. van der
Committee member(s)
Blauw, G.J.; Hol, E.M.; Weiskopf, N.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/3147341
ISBN(s)
9789464163896