Pathophysiology of the GH/IGF-1 axis : long-term consequences on joints and bone

Author(s):
Claessen, K.M.J.A.
Published
2014
Publication type
Doctoral Thesis

Abstract

In this thesis, a number of observations are described in acromegaly patients with cured or biochemically well-controlled disease during long-term follow-up. These observations focus on the long-term consequences of the disease on joints and bone. In addition, we investigated the role of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF-1) axis, including the possible effects of the exon 3 deleted GH receptor (d3-GHR) polymorphism, in patients with primary osteoarthritis (OA) that have serum IGF-1 levels within the normal range. Finally, we studied the long-term consequences of recombinant human GH (rhGH) replacement in GH Deficient (GHD) adults, focusing on the cardiovascular effects and the effects on bone in comparison to healthy controls.

Metabolic syndromeGHDVertebral fracturesIGF-1GHJointsBoneAcromegaly
Defense date
2014-12-17
Language
English
Supervisor(s)
Pereira, A.M.; Kloppenburg, M.
Advisor(s)
Biermasz, N.R.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/30244
ISBN(s)
9789461087980

Funding

Sponsorship
Ferring BV, Pfizer BV, Novartis Pharma BV, Novo Nordisk BV, Ipsen Farmaceutica BV, Sanofi-Aventis BV, ABN AMRO