MR assessment of end-organ damage in the metabolic syndrome and diabetes mellitus

Author(s):
Schinkel, L.D. van
Published
2014
Publication type
Doctoral Thesis

Abstract

The first part of this thesis focuses on assessing end-organ damage in individuals with the metabolic syndrome and diabetes mellitus using magnetic resonance imaging (MRI) and spectroscopy (1H-MRS). We performed cross sectional and intervention studies to investigate the contribution of obesity, dietary conditions, metabolic environment and exogenous disruptors (chemotherapy) to cardiovascular end-organ damage and the reversibility of this damage with a low caloric diet. The effects of interventions, dietary as well as non-dietary, were explored using imaging technology. As ethnicity is an important aspect of the pathophysiology in diabetes mellitus, we also examined the influence of ethnic factors on diabetes mellitus and its complications. The second part of this thesis focuses on safety, feasibility and implementation of innovative MR techniques at higher field strengths for assessment of cardiovascular disease.

End-organ damageEthnicityDietary interventionsMRICardiovascular functionDiabetes mellitus
Defense date
2014-10-07
Language
English
Supervisor(s)
Smit, J.W.A.; Roos, A. de; Lamb, H.J.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/29081
ISBN(s)
9789461695500

Funding

Sponsorship
Nederlandse Hartstichting, Novo Nordisk B.V., Boehringer Ingelheim B.V., Servier Nederland Farma B.V., Ipsen Farmaceutica B.V., Guerbet Nederland B.V. and Sanofi Nederland B.V.