Facing the phases of Mycobacterium tuberculosis : hunting for better TB vaccines

Author(s):
Commandeur, S.
Published
2014
Publication type
Doctoral Thesis

Abstract

Currently, only one tuberculosis (TB) vaccine is available: Mycobacterium bovis Bacille Calmette-Gu_rin (BCG). This vaccine induces highly variable protection against pulmonary TB, the most common and contagious form of TB. There is an urgent need for an effective TB vaccine which is safe also in the immunocompromised host. The main focus of this thesis was to identify Mycobacterium tuberculosis (Mtb) infection phase related antigens and to evaluate these as potential antigens for TB vaccines. The studies presented in this thesis describe: (i) the immunogenic potential of two previously described sets of antigens; resuscitation promoting factor (Rpf) and dormancy regulon encoded (DosR) antigens, (ii) the identification and immunogenicity of a third set of antigens known as in vivo expressed Mtb (IVE-TB) antigens, (iii) the protective value of IVE-TB antigen Rv2034 and (iv) the analysis of Rv2034-specific T cell r esponses at the clonal level. Together, these data illustrate the vaccine potential of infection phase related antigens.

Addaptive immunityT-cellsVaccineMycobacterium tuberculosisTuberculosisDormancyInfectious diseases
Defense date
2014-01-22
Language
English
Supervisor(s)
Ottenhoff, T.H.M.
Advisor(s)
Geluk, A.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/23080
ISBN(s)
9789461085764