Alternative polymerases in the maintenance of genome stability in C. elegans

Author(s):
Roerink, S.F.
Published
2014
Publication type
Doctoral Thesis

Abstract

In this thesis I describe the developmental role of the Y-family polymerases Pol Eta, Pol Kappa and Rev1 in protection against exogenous and endogenous damage in C. elegans. Furthermore I identify a new role for the A-family Polymerase Pol Theta in repair of replication-associated breaks.

Double strand break repairPolymerasesWhole genome analysisC. elegansTranslesion synthesisDNA repairGenetics
Defense date
2014-01-09
Language
English
Supervisor(s)
Mullenders, L.H.F.
Advisor(s)
Tijsterman, M.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/22970
ISBN(s)
9789064647253

Funding

Sponsorship
For printing of the thesis: Greiner Bio-One