NMR studies of protein-small molecule and protein-peptide interactions

Guan, J. (2013)

Doctoral Thesis

The work described in this thesis focuses on the application of various NMR techniques to the study of interactions between proteind and small molecules and proteins and peptides, incluiding the well-established classical NMR approaches, and the precently developed paramagnetic NMR methods. computational tools have been used to complement and visualized the experimental data.

• Protein-ligand interactions
• Paramagnetic NMR
• Computaional modelling
• Pseudocontact shift
• Ligand binding
• Fragment-based drug discovery
• FKBP
• Plastocyanin
• Encounter complex
• Tetralysine peptide
• Molecular modelling
• NMR spectroscopy

• All authors: Guan, J.
• Supervisor: Ubbink, M.
• Co-supervisor: Siegal, G.
• Committee: Brouwer, J.; Vlijmen, H. van; Duynhoven, J. van; Luchinat, C.; Stelt, M. van der
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University
• Date: 2013-12-02
• ISBN (print): 9789462034501