Adherence to antiretroviral combination therapy in children : what a difference half a day makes...

Author(s):
Piana, C.
Published
2013
Publication type
Doctoral Thesis

Abstract

Adherence to antiretroviral combination therapy in children. What a difference half a day makes____ has explored the opportunities to support evidence generation and extrapolation across populations, with special focus on the selection of the dose, the optimisation of dosing regimens and the impact of patient behaviour towards antiretroviral treatment. A model-based approach for the evaluation of covariate effects and forgiveness of non-adherence, which may allow simplification of current dosing regimens taking into consideration inadequate compliance and its implication for efficacy and drug resistance, has been proposed. In conjunction with clinical trial simulations, this thesis addressed the possibility to evaluate relevant clinical scenarios and predict treatment outcome of simplified dosing regimens, taking into account the differences in the patterns of drug intake and the pharmacokinetic-pharmacodynam ic properties of antiretroviral drugs.

Forgiveness of non-adherencePredictive pharmacokinetic modelsClinical trial simulationsModel-based researchDrug combinationsCovariate analysisAntiretroviral drugsPaediatric populationsAdherence to therapy
Defense date
2013-10-31
Language
English
Supervisor(s)
Danhof, M.
Advisor(s)
Della Pasqua, O.E.
Qualification
Ph.D.
Degree granting institution
Faculty of Science, Leiden University, Leiden
Publisher
Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University
hdl
1887/22077
ISBN(s)
9789090277837