Practical aspects of cervical cancer

Author(s):
Tillaart, S.A.H.M. van den
Published
2013
Publication type
Doctoral Thesis

Abstract

The thesis describes studies on practical aspects of cervical cancer, concering surgical considerations, and aspects of tumour behaviour and tumour spread. The thesis comprises studies on: the comparison of nerve-sparing and non-nerve-sparing radical hysterectomy for cervical cancer; a new surgical technique called the __Swift__ operation, a modification of the Leiden nerve-sparing radical hysterectomy; the use of distilled water to achieve adequate haemostasis during oncologic surgery; patterns of parametrial involvement in cervical cancer; scar recurrences after surgery for cervical cancer; the morphologic characteristics __Barrel Index__ and intra uterine fluid as possible predictors for survival after cervical cancer surgery; the relation between genetic changes (loss of heterozygosity and copy number alterations) and clinical parameters in a whole genome SNP-analysis of bulky cervical tumours. Furthermore, the visualisation of the __Morphogenetic Unit__ on MRI and per-operative is described.

Tumor behaviorSNP analysisScar recurrenceParametriaOncologic surgeryNerve-sparing surgeryMorphogenetic unitGynecologic oncologyDistilled waterCervical cancer
Defense date
2013-06-27
Language
English
Supervisor(s)
Fleuren, G.J.; Peters, A.A.W.; Trimbos, J.B.M.Z.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/21033

Funding

Sponsorship
Abbott, Astellas Pharma BV, BD biosciences, Bureau Medische Automatisering BV, Carl Zeiss BV, ChipSoft, ERBE, GlaxoSmithKline BV, Medical Dynamics, Memidis Pharma BV, Roche, Smith & Nephew Nederland