Fatty acid metabolism and metabolic inflammation : two important players in the development of insulin resistance

Author(s):
Vroegrijk, I.O.C.M.
Published
2013
Publication type
Doctoral Thesis

Abstract

The metabolic syndrome is a multi-component condition that includes obesity hypertriglyceridemia and insulin resistance. The prevalence of the metabolic syndrome is rising world-wide and is associated with an increased risk for the development of cardiovascular diseases and type 2 diabetes. In the past decades it has been discovered that obese persons have slightly elevated markers of inflammation in their plasma. This low-grade chronic inflammation, also called metabolic inflammation, is hypothesized to function as the link between the various components of the metabolic syndrome. In this thesis, it is evaluated how alterations in triglyceride (TG) and fatty acid (FA) metabolism and inflammatory pathways interact in the development of obesity and insulin resistance, which are both primary risk factors for the development of type 2 diabetes

VLDL productionReduced iso-alpha acidsMetabolic syndromeMetabolic inflammationLipid metabolismInsulin resistanceAnti-inflammationAntibody effector pathwaysAdipocyte biology
Defense date
2013-05-16
Language
English
Supervisor(s)
Havekes, L.M.; Romijn, J.A.; Willems Van Dijk, K.
Advisor(s)
Voshol, P.J.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
Publisher
Department of Endocrinology and Metabolic Diseases, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
hdl
1887/20887

Funding

Sponsorship
Het onderzoek is gesponsord door: NWO 917.76.301, the Dutch Diabetes Research Foundation (2005.01.003) en the seventh framework program of the EU-funded LipidomicNet (202272).