Sclerostin : a key regulator of bone metabolism

Author(s):
Lierop, A.H.J.M. van
Published
2013
Publication type
Doctoral Thesis

Abstract

In this thesis we studie the role of sclerostin in bone metabolism. We studied patients with the rare bone sclerosing disorders sclerosteosis and van Buchem disease, both caused by sclerostin deficiency. We further studied the role of sclerostin in different bone related disorders.

Van buchem diseaseSclerostinSclerosteosisBone resorptionBone formation
Defense date
2013-02-14
Language
English
Supervisor(s)
Papapoulos, S.E.
Advisor(s)
Hamdy, N.A.T.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/20541
ISBN(s)
9789461916082

Funding

Sponsorship
The research descibed in this thesis was carried out within the FP7 program TALOS, financied by the European Union (HEALTH-F2-2008-20199, TALOS). Publication of this thesis was financially supported by: Anna Fonds, J.E. Jurriaanse stichting, Nederlandse Vereniging voor Calcium en Bot, Amgen B.V., Eli Lilly Nederland B.V, Novartis Pharma B.V., Servier Nederland Farma B.V., Goodlife Healthcare B.V. and UCB Pharma B.V.