Herpesvirus infections in immunocompromised patients : treatment, treatment failure and antiviral resistance

Author(s):
Beek, M.T. van der
Published
2012
Publication type
Doctoral Thesis

Abstract

The research described in this thesis aims to study determinants of the course and outcome of treatment of herpesvirus infections in immunocompromised patients. Both viral factors, such as antiviral resistance, and patient factors, including immunological parameters, were investigated. Techniques to study antiviral resistance were optimized for use in a clinical diagnostic setting. The aim of this research is to improve and facilitate management of herpesvirus infections in immunocompromised patients.

liver transplantationrenal transplantationhematopoietic stem cell transplantationantiviral resistanceantiviral treatmentCytomegalovirusVaricella-zoster virusHerpes simplex virus type 1
Defense date
2012-11-20
Language
English
Supervisor(s)
Kroes, A.C.M.
Advisor(s)
Vossen, A.C.T.M.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/20141
ISBN(s)
9789090268507

Funding

Sponsorship
Research: none. Printing thesis: Netherlands Society of Medical Microbiology (NVMM) and the Royal Netherlands Society for Microbiology (KNVM), GlaxoSmithKline and Novartis.