Huntington's disease : quantifying structural brain changes

Bogaard, S.J.A. van den (2012)

Doctoral Thesis

The aim of this thesis was to find potential MRI biomarkers for Huntington__s disease (HD). Therefore, after an overview of the current literature on MRI biomarkers, followed by examinations of volumetric MRI, magnetization transfer imaging (MTI), diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS) were applied in patients in different disease stages of HD. The main conclusions demonstrate that choosing the optimal biomarker for evaluating therapeutic effects is dependent on the disease stage and therapeutic compound. To evaluate the premanifest stages of the disease volumetric MRI and DTI are most suitable. When the transition period is the desired timeframe for evaluation, also MRS can be very useful, especially if the compound in question has a direct potential influence on certain pathogenic pathways which in turn have an impact on specific metabolites. Future research should focus on combining multiple imaging techniques; __multimodal imaging__. A composite MRI biomarker has the potential to distinguish between disease groups more accurately than a single biomarker and in this way improve the evaluation of therapeutic compounds.

• MRS
• MRI
• Movement disorder
• Manifest
• Huntington's Disease
• DTI
• Disease onset
• Brain
• Biomarker
• Structural changes
• Premanifest
• Neurodegenerative
• MTI

• All authors: Bogaard, S.J.A. van den
• Supervisor: Roos, R.A.C.; Buchem, M.A. van
• Co-supervisor: Grond, J. van der
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2012-11-14
• ISBN (print): 9789090269788
• Sponsorship: The Dutch Hungtington's Disease foundation, Guerbet Nederland B.V., Philips Medical Systems Nederland B.V., Sectra Benelux B.V., Lundbeck B.V. and Novartis Pharma B.V.