Epidemiological explorations on Clostridium difficile Infection

Author(s):
Goorhuis, A.
Published
2011
Publication type
Doctoral Thesis

Abstract

This thesis describes the epidemiology of emerging infections with Clostridium difficile. Outbreaks of severe disease with high mortality were found to be associated with certain types of this bacterium and type specific risk factors were identified. Moreover, highly discriminatory typing techniques were useful in understanding clonal disseminations across healthcare institutions.

Risk factorsPCR-ribotypes 027 and 078MortalityMolecular typing techniquesMLVAClostridium difficileCattle breeding industry
Defense date
2011-10-12
Language
English
Supervisor(s)
Dissel, J.T. van; Kroes, A.C.M.
Advisor(s)
Kuijper, E.J.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/17925
ISBN(s)
9789090263472

Funding

Sponsorship
Abbott B.V., Astellas B.V., Boehringer-Ingelheim B.V., Clean Air Techniek B.V., Eurocept B.V., Gilead B.V., Janssen-Cilag B.V., MSD B.V., Pfizer B.V., SanoMi-Pasteur-MSD N.V. and ViiV Healthcare B.V.