Site-selective incorporation of alpha- and beta-amino acid derivatives : towards new gramicidin S-based bactericides

Author(s):
Knaap, M. van der
Published
2010
Publication type
Doctoral Thesis

Abstract

The effect of the incorporation of alpha- and beta-amino acids in model peptide gramicidin S is described. Several techniques were applied, such as NMR and X-ray crystallography. In addition the activity of the newly obtained peptides towards bacterial and mammalian cell membranes was investigated.

Cyclic peptidesUnnatrual amino acidsBeta-amino acidsOrganic synthesisPeptide engineeringNMRGramicidin S
Defense date
2010-09-08
Language
English
Supervisor(s)
Marel, G.A. van der; Overkleeft, H.S.
Advisor(s)
Overhand, M.
Qualification
Ph.D.
Degree granting institution
Faculty of Science, Leiden University, Leiden
hdl
1887/15935

Funding

Sponsorship
STW