Heart and large vessel interaction in congenital heart disease, assessed by magnetic resonance imaging

Author(s):
Grotenhuis, H.B.
Published
2009
Publication type
Doctoral Thesis

Abstract

The main objective of the current thesis is to assess aortic wall elasticity and aortic dimensions and their impact on aortic valve competence and LV function in patients with a bicuspid aortic valve, transposition of the great arteries, tetralogy of Fallot and patients after the Ross procedure, with the use of MRI. In addition, MRI was also used to test whether a similar interaction is present between pulmonary artery dynamics and the right ventricle in the above mentioned entities. Chapter 2 reviews the 5 most common entities of inherited connective tissue disorders and classical congenital heart disease with intrinsic aortic wall abnormalities, with description of the potential role of MRI in their evaluation and management. Chapter 3 describes in vivo validation, as well as testing of reproducibility of aortic pulse wave velocity as assessed with MRI, as indicator of aortic elasticity. Chapter 4 studies aortic elasticity, aortic valve competence and LV function in non-stenotic bicuspid aortic valve patients. Chapters 5 and 6 describe aortic elasticity, aortic valve competence and LV function, and the results of pulmonary flow dynamics in relationship with right ventricular function in patients after the arterial switch operation, respectively. Chapter 7 addresses aortic dimensions and elasticity in conjunction with aortic valve and LV function in patients with repaired tetralogy of Fallot after pulmonary valve replacement. Chapter 8 describes the outcome of patients who have previously undergone the Ross procedure in our institution for a dysfunctioning aortic valve. Chapter 9 studies aortic elasticity, aortic valve competence and LV function in patients after the Ross procedure. Finally, Chapter 10 describes the results of pulmonary flow dynamics in relationship with right ventricular function in patients after the Ross procedure. In Chapter 11 all studies presented in this thesis are summarized and future directions are discussed.

MRIAortaPulmonary ArteryDistensibility
Defense date
2009-09-10
Language
English
Supervisor(s)
Roos, A. de; Ottenkamp, J.
Advisor(s)
Westenberg, J.J.M.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/14027
ISBN(s)
9789064643514

Funding

Sponsorship
Nederlandse Hartstichting, Astra Zeneca B.V., Bayer B.V., Philips Medical Systems, Boehringer-Ingelheim B.V., J.E. Jurriaanse Stichting, Guerbet Nederland B.V., Laboratorium voor Klinische en Experimentele Beeldverwerking (LKEB)