New fluorescent platinum (II) complexes containing anthracene derivatives as a carrier ligand : synthesis, characterization and in vitro studies

Abstract

In this thesis new fluorescent platinum(II) compounds are presented. All these new compounds were designed to overcome the cisplatin-resistance, using bulky ligands surrounding the platinum(II) ion. To study their biological activity two cell lines were chosen, the human ovarian carcinoma sensitive to cisplatin (A2780), and its resistant counterpart (A2780R). This thesis is divided in two parts: Part I: New fluorescent platinum(II) compounds containing 9-anthryl pyridyl enone as carrier ligand (chapters 2,3 and 4), and Part II: A new fluorescent platinum(II) compound containing N,N__-bis-(anthracen-9-ylmethyl)propane-1,3-diamine as a carrier ligand (chapter 5, 6 and 7).