Strategies in prevention and treatment of prosthetic joint infections

Author(s):
Veltman, E.S.
Published
2020
Publication type
Doctoral Thesis

Abstract

We studied the prevention and treatment of prosthetic joint infections. This topic is of interest because the number of annually performed arthroplasty procedures is rising worldwide.

Antibiotics are prophylactically administered to arthroplasty patients, but to date it remained unclear how many doses of prophylaxis provided the best protection. 90% of hospitals provide multiple doses, while 10% of hospitals administer a single dose prophylaxis.

Our study shows that, with 242.179 included patients from the LROI database, there seems to be no difference in the risk of complete revision for infection between single dose and multiple dose prophylaxis.

We have also evaluated several treatment options for two-stage revision of infected hip and knee prostheses. The use of a functional articulating antibiotic loaded spacer leads to a comparable infection eradication rate, improved patient reported outcome and less complications compared to a prefabricated standard spacer

Prosthetic join infection (PJI)Hip arthroplastyKnee arthroplastyTwo-stage revisionAntibiotic prophylaxis
Defense date
2020-12-09
Language
English
Supervisor(s)
Nelissen, R.G.H.H.; Poolman, R.W.
Advisor(s)
Mooijen, D.J.F.
Committee member(s)
Dijkstra, P.D.S.; Groenwold, R.H.H.; Jutte, P.C.; Wouthuyzen-Bakker, M.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/138638
ISBN(s)
9789464210903