Persistent URL of this record https://hdl.handle.net/1887/138374
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
The specific contribution of lipoprotein fractions to steroidogenesis is unknown. We lowered the (very) large-density lipoprotein fraction in ApoE-KO mice, resulting in a decreased GC output. ApoE is also produced within the adrenal where its local role is unclear. By transplanting an ApoE KO adrenal into an adrenalectomized wild-type mouse we revealed that local ApoE does not impact GC synthesis. Show less
- All authors
- Sluis, R.J. van der
- Supervisor
- Eck, M. van
- Co-supervisor
- Hoekstra, M.
- Committee
- Irth, H.; Bouwstra, J.A.; Meijer, O.C.; Quax, P.H.A.; Salvatori, D.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Leiden Academic of Drug Research (LACDR) , Faculty of Science , Leiden University
- Date
- 2020-11-19
- ISBN
- 9789463326889
Funding
- Sponsorship
- Dutch Heart foundation