Oxacarbenium ion intermediates in the stereoselective synthesis of anionic oligosaccharides

Author(s):
Dinkelaar, J.
Published
2009
Publication type
Doctoral Thesis

Abstract

In this thesis new strategies towards biologically active oligosaccharides are described. In addition a detailed mechanistic study is performed to investigate the stereodirecting capacity of glycosyl C-5 substituents in systems that were devoid of any other stereodirecting factors. The postulated mechanism described here can aid in the design of glycosylation strategies.

AlginateCarbohydratesHyaluronanOligosaccharidesOxacarbenium ionThioglycosides
Defense date
2009-05-13
Language
English
Supervisor(s)
Marel, G.A. van der
Qualification
Ph.D.
Degree granting institution
Faculty of Science, Leiden University, Leiden
hdl
1887/13791