Exploring and modulating the tumor immune microenvironment: Towards improving patient outcomes of immunotherapy in lung cancer

Author(s):
Theelen, W.S.M.E.
Published
2020
Publication type
Doctoral Thesis

Abstract

This thesis sought to obtain a better understanding of the composition of the immune microenvironment in NSCLC and how to modulate this tumor immune microenvironment by RT to induce amplified antitumor immune responses to ICIs in advanced NSCLC patients. In the first part of this thesis, a multiangular approach of a combination of protein and mRNA expression with clinicopathological characteristics in a large cohort of early stage, resected NSCLC samples will be discussed. The second part focusses on the immune modulating effects of RT, in particular when combined with immunotherapy treatment in metastatic NSCLC.

NSCLCGene expressionPD-L1ImmunotherapyRadiotherapyAbscopal effect
Defense date
2020-10-21
Language
English
Supervisor(s)
Baas P., Heuvel M.M. van den
Committee member(s)
Marijnen, C.A.M.; Keyser-Borst, J.G.; Hiemstra, P.S.; Hoeven, J.J.M. van der; Ruysscher, D.K.M. de; Becker-Commissaris, A.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/137007
ISBN(s)
9789464230109