Targeting of antigen presenting cells with mannosylated conjugates

Author(s):
Hogervorst, T.P. (0000-0002-4686-6251)
Published
2020
Publication type
Doctoral Thesis

Abstract

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

MannosylationAntigen-conjugatespeptidic-conjugatesChemical ImmunologyC-type lectin receptorToll like receptorDC-SIGNMannose receptorLangerin
Defense date
2020-03-17
Language
English
Supervisor(s)
Codée, J.C.D.
Advisor(s)
Marel, G.A. van der
Committee member(s)
Overkleeft, H.S.; Brouwer, J.; Kooyk, Y. van; Filippov, D.V.; Verdoes, M.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/136534
ISBN(s)
9789463758161