The microenvironment in colorectal cancer: An integrative histopathological, transcriptomic and metabolomic approach

Author(s):
Sandberg, T.P.
Published
2020
Publication type
Doctoral Thesis

Abstract

Colorectal tumours with high stromal content have a poor prognosis. In part 1, I investigated, at the protein and gene expression levels, the composition of these tumours in comparison to stroma-low tumours. In part 2, KRAS mutant colorectal cancer cell lines had a different metabolism compared to KRAS wild type after inhibition of mTORC1. This may contribute to therapeutic resistance.

Colorectal cancerGalectin-1Fibroblast activation proteinTumour stromaTumour-stroma ratioKRAS mutationAspartateConsensus molecular subtypes (CMS)
Defense date
2020-09-08
Language
English
Supervisor(s)
Tollenaar, R.A.E.M.; Morreau, H.
Advisor(s)
Mesker, W.E.
Committee member(s)
Smit, V.T.H.B.M.; Krieken, J.H.J.M. van; Le Dévédec, S.E.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/136533
ISBN(s)
9789463808491