Generation of antigen-specific T cell immunity through T cell receptor gene transfer

Abstract

Cancer cells often escape the attack of immune cells because they originate from self-tissue. Through T cell receptor gene transfer it is possible to equip peripheral T cells with a desired specificity, and this strategy may be useful to generate tumor-specific T cells for the treatment of cancer in humans. This thesis describes several aspects in the functionality, safety and longevity of T cells modified by T cell receptor gene transfer in animal models.