Dimeric ligands for GPCRs involved in human reproduction: synthesis and biological evaluation

Author(s):
Bonger, K.M.
Published
2008
Publication type
Doctoral Thesis

Abstract

Dimeric ligands for G-protein coupled receptors that are involved in human reproduction, namely the gonadotropin releasing hormone receptor, the luteinizing hormone receptor and the follicle-stimulating hormone receptor, were synthesized and biologically evaluated.

Dimeric ligandsGonadotropin receptorFollicle stimulating hormone receptorLuteinizing hormone receptorReproduction GPCRs
Defense date
2008-12-19
Language
English
Supervisor(s)
Overkleeft, H.S.; Marel, G.A. van der
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/13368

Funding

Sponsorship
The project has been financially supported by the Council for Chemical Sciences of the Netherlands Organization for Scientific Research (CW-NWO) and the Schering-Plough Research Institute (Oss).