Lifestyle and venous thrombosis

Author(s):
Pomp, E.R.
Published
2008
Publication type
Doctoral Thesis

Abstract

In the Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis (MEGA study), a large population-based case-control study, we investigated lifestyle factors as risk factors for venous thrombosis. Overweight, smoking and alcohol consumption were addressed and pregnancy and the postpartum period were evaluated in women. Due to the large sample size of the study it was possible to investigate the joint effect of these risk factors with important genetic risk factors for venous thrombosis such as the factor V Leiden and the prothrombin 20210A mutation. In addition to these lifestyle related risk factors, two polymorphisms within the promoter region of the protein C gene were studied as risk factors for venous thrombosis and the influence of genotypic variation on plasma protein C levels was assessed. Finally, we described our experience with the inclusion of two different control groups in the MEGA study.

Alcohol consumptionCase-control studyFactor V Leiden mutationMultiple control groupsObesityPregnancyProtein C polymorphismsProthrombin 20210A mutationSmokingVenous thrombosis
Defense date
2008-12-03
Language
English
Supervisor(s)
Rosendaal, F.R.
Advisor(s)
Doggen, C.J.M.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/13308
ISBN(s)
9789085594550

Funding

Sponsorship
The Netherlands Heart foundation J.E. Jurriaanse Stichting