Cardiac bone marrow cell injection for chronic ischemic heart disease

Author(s):
Beeres, S.L.M.A.
Published
2007
Publication type
Doctoral Thesis

Abstract

The aim of this thesis was to evaluate the safety, feasibility and potential efficacy of autologous bone marrow mononuclear cell injection in patients with chronic ischemic heart disease. For this purpose, 30-100 million autologous bone marrow cells were injected into the ischemically-damaged myocardium of 50 patients with chronic ischemic heart disease. The results of the current studies demonstrate that intramyocardial injection of autologous bone marrow mononuclear cells in patients with chronic ischemic heart disease is feasible and safe. In particular, the electrophysiological properties of the injected myocardium remain unchanged and aggravation of coronary atherosclerosis is not observed. Moreover, autologous bone marrow cell injection seems to be associated with a beneficial effect on anginal symptoms, myocardial perfusion and left ventricular (systolic and diastolic) function. The beneficial effects of cardiac cell therapy appear to be sustained over a longer period of follow-up.

Ischemic heart diseaseBone marrow cellsAnginal symptomsLeft ventricular functionMyocardial perfusion
Defense date
2007-10-17
Language
English
Supervisor(s)
Schalij, M.J.; Bax, J.J.
Advisor(s)
Atsma, D.E.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
Publisher
Department of Cardiology, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
hdl
1887/12421
ISBN(s)
9789090222110