Altered levels of coagulation factors in bleeding and thrombosis

Abstract

Blood coagulation is a complex system in which the proteins of the coagulation cascade play an important role. Aberrations in pro- or anticoagulant protein levels may be at the basis of coagulation-related pathological events, such as bleeding or thrombosis. Here the relations of altered coagulation factor levels and venous thromboembolism, the tissue factor threshold which needs to be overcome to initiate coagulation and the in vitro validation of APC-resistant FV as a possible alternative treatment of factor XI deficiency are explored.