Metabolic Stress Triggers Immune Escape by Tumors

Author(s):
Nunes, J.B.; Everts, B.
Published
2019
Publication type
Article / Letter to editor

Abstract

There is major interest in understanding the role of the tumor microenvironment in immune escape. In a recent report, Marijt et al. shed light on the signaling cascade that leads to decreased surface expression of MHC class I by tumor cells triggered by low oxygen and glucose availability, revealing new opportunities for therapeutic intervention.

Date issued
2019-11-01
Language
English
Publisher
CELL PRESS
Is part of
TRENDS IN CANCER (2019), Vol. 5, no. 11, p. 656-658
hdl
1887/122198
doi
10.1016/j.trecan.2019.09.001