A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Author(s):
Lee, S.J. van der; Conway, O.J.; Jansen, I.; Carrasquillo, M.M.; Kleineidam, L.; Akker, E. van den; Hernandez, I.; Eijk, K.R. van; Stringa, N.; Chen, J.A.; Zettergren, A.; Andlauer, T.F.M.; Diez-Fairen, M.; Simon-Sanchez, J.; Lleo, A.; Zetterberg, H.; Nygaard, M.; Blauwendraat, C.; Savage, J.E.; Mengel-From, J.; Moreno-Grau, S.; Wagner, M.; Fortea, J.; Keogh, M.J.; Blennow, K.; Skoog, I.; Friese, M.A.; Pletnikova, O.; Zulaica, M.; Lage, C.; Rojas, I. de; Riedel-Heller, S.; Illan-Gala, I.; Wei, W.; Jeune, B.; Orellana, A.; Bergh, F.T.; Wang, X.; Hulsman, M.; Beker, N.; Tesi, N.; Morris, C.M.; Indakoetxea, B.; Collij, L.E.; Scherer, M.; Morenas-Rodriguez, E.; Ironside, J.W.; Berckel, B.N.M. van; Alcolea, D.; Wiendl, H.; Strickland, S.L.; Pastor, P.; Rodriguez Rodriguez, E.; Boeve, B.F.; Petersen, R.C.; Ferman, T.J.; Gerpen, J.A. van; Reinders, M.J.T.; Uitti, R.J.; Tarraga, L.; Maier, W.; Dols-Icardo, O.; Kawalia, A.; Dalmasso, M.C.; Boada, M.; Zettl, U.K.; Schoor, N.M. van; Beekman, M. (0000-0003-0585-6206); Allen, M.; Masliah, E.; Munain, A.L. de; Pantelyat, A.; Wszolek, Z.K.; Ross, O.A.; Dickson, D.W.; Graff-Radford, N.R.; Knopman, D.; Rademakers, R.; Lemstra, A.W.; Pijnenburg, Y.A.L.; Scheltens, P.; Gasser, T.; Chinnery, P.F.; Hemmer, B.; Huisman, M.A.; Troncoso, J.; Moreno, F.; Nohr, E.A.; Sorensen, T.I.A.; Heutink, P.; Sanchez-Juan, P.; Posthuma, D.; Clarimon, J.; Christensen, K.; Ertekin-Taner, N.; Scholz, S.W.; Ramirez, A.; Ruiz, A.; Slagboom, E.; Flier, W.M. van der; Holstege, H.; DESGESCO Dementia Genetics; EADB Alzheimer Dis European; IFGC Int FTD-Genomics; IPDGC Int Parkinson Dis Genomics; RiMod-FTD Risk Modifying; Netherlands Brain Bank NBB; GIFT Genetic Invest
Published
2019
Publication type
Article / Letter to editor
Alzheimer's diseaseFrontotemporal dementiaDementia with Lewy bodiesProgressive supranuclear palsyParkinson's diseaseAmyotrophic lateral sclerosisMultiple sclerosisNeurodegenerative diseaseLongevityPLCG2Phospholipase C Gamma 2
Date issued
2019-08-31
Language
English
Is part of
Acta Neuropathologica (2019), Vol. 138, no. 2, p. 237-250
hdl
1887/120374
doi
10.1007/s00401-019-02026-8