The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

Author(s):
Hall, T. van; Oliveira, C.C.; Joosten, S.A.; Ottenhoff, T.H.M.
Published
2010
Publication type
Article / Letter to editor

Abstract

The non-polymorphic MHC molecule Qa-1 and its human counterpart HLA-E present monomorphic signal peptides to innate receptors and thereby regulate lymphocyte activity. Under stress, this peptide content is replaced with a surprisingly diverse repertoire of novel peptides that are associated with heat-shock proteins, infectious agents or antigen processing defects.

Date issued
2010-11-30
Language
English
Is part of
hdl
1887/120180
doi
10.1016/j.micinf.2010.07.011