Prognostic value and clinicopathologic characteristics of L1 cell adhesion molecule (L1CAM) in a large series of vulvar squamous cell carcinomas

Author(s):
Trietsch, M.D.; Oonk, M.H.M.; Hawinkels, L.J.A.C.; Bor, R.; Eendenburg, J.D.H. van; Ivanova, Z.; Peters, A.A.W.; Nijman, H.W.; Gaarenstroom, K.N.; Bosse, T.
Published
2016
Publication type
Article / Letter to editor

Abstract

Conclusion: This is the first study to show high L1CAM-expression at the infiltrating margin of VSCC's. L1CAM-expressing VSCCs had a significantly worse prognosis compared to L1CAM-negative tumours. The highest expression was observed in spindle-shaped cells, where it might be correlated to their invasive capacity.

L1 cell adhesion moleculeL1CAMvulvar cancersquamous cell carcinomasurvival
Date issued
2016-05-03
Language
English
Publisher
IMPACT JOURNALS LLC
Is part of
Oncotarget (2016), Vol. 7, no. 18, p. 26192-26205
hdl
1887/117205
doi
10.18632/oncotarget.8353