What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?

Abstract

Couples of whom the woman has had a miscarriage have two major concerns: the

cause and possible risk of recurrence. Unfortunately, a significant proportion of cases of

recurrent miscarriage (RM) remain unexplained despite detailed investigation. Because

data suggest that regulatory T cells (Treg) are involved in the maternal acceptance of the allogeneic foetus, RMcould possibly be explained by a disturbance of the Treg network. The possible role of Tregs in RM is described in this review, as well as their potential application in diagnostics and therapeutic intervention trials. Couples of whom the woman has had a miscarriage have two major concerns: the cause and possible risk of recurrence. Unfortunately, a significant proportion of cases of recurrent miscarriage (RM) remain unexplained despite detailed investigation. Because data suggest that regulatory T cells (Treg) are involved in the maternal acceptance of the allogeneic foetus, RMcould possibly be explained by a disturbance of the Treg network. The possible role of Tregs in RM is described in this review, as well as their potential application in diagnostics and therapeutic intervention trials.