Circulating Interleukin-10 and Risk of Cardiovascular Events A Prospective Study in the Elderly at Risk

Author(s):
Welsh, P.; Murray, H.M.; Ford, I.; Trompet, S.; Craen, A.J.M. de (0000-0001-9314-123X); Jukema, J.W.; Stott, D.J.; McInnes, I.B.; Packard, C.J.; Westendorp, R.G.J. (0000-0002-0672-8372); Sattar, N.; PROSPER Study Grp
Published
2011
Publication type
Article / Letter to editor

Abstract

Objective-The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD). Methods and Results-In the PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) cohort, we related baseline concentrations of circulating IL-10 to risk of CVD events in a nested case (n=819)-control (n=1618) study of 3.2 years of follow-up. Circulating IL-10 showed few strong associations with classical risk factors but was positively correlated with IL-6 and C-reactive protein. IL-10 was positively associated with risk of CVD events (odds ratio [ OR] 1.17, 95% CI 1.05 to 1.31 per unit increase in log IL-10) after adjusting for classical risk factors and C-reactive protein. Furthermore, IL-10 was associated more strongly with CVD risk among those with no previous history of CVD (OR 1.42, 95% CI 1.18 to 1.70), compared with those with previous CVD (OR 1.04, 95% CI 0.90 to 1.19; P=0.018). Overall, IL-10 showed a modest ability to add discrimination to classical risk factors (C-statistic +0.005, P=0.002). Conclusion-Baseline circulating levels of the antiinflammatory IL-10 are positively associated with risk of CVD among the elderly without prior CVD events, although the association is less evident in those with a history of CVD. Additional epidemiological and mechanistic studies investigating the role of IL-10 in CVD are warranted. (Arterioscler Thromb Vasc Biol. 2011;31:2338-2344.)

cardiovascular disease prevention cytokines epidemiology risk factors inflammation coronary-heart-disease c-reactive protein antiinflammatory cytokine interleukin-10 unstable angina artery-disease atherosclerosis mice inflammation serum pravastatin
Date issued
2011-10-31
Language
English
Is part of
Arteriosclerosis, Thrombosis, and Vascular Biology (2011), Vol. 31, no. 10, p. 2338
hdl
1887/116701
doi
10.1161/ATVBAHA.111.231795