The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468

Author(s):
Treiber, A.; Kanter, R. de; Roch, C.; Gatfield, J.; Boss, C.; Raumer, M. von; Schindelholz, B.; Muehlan, C.; Gerven, J. van; Jenck, F.
Published
2017
Publication type
Article / Letter to editor
Date issued
2017-09-01
Language
English
Is part of
Journal of Pharmacology and Experimental Therapeutics (2017), Vol. 362, no. 3, p. 489-503
hdl
1887/116424
doi
10.1124/jpet.117.241596