Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Author(s):: Strawbridge, R.J.; Silveira, A.; Hoed, M. den; Gustafsson, S.; Luan, J.A.; Rybin, D.; Dupuis, J.; Li-Gao, R.F.; Kavousi, M.; Dehghan, A.; Haljas, K.; Lahti, J.; Gadin, J.R.; Backlund, A.; Faire, U. de; Gertow, K.; Giral, P.; Goel, A.; Humphries, S.E.; Kurl, S.; Langenberg, C.; Lannfelt, L.L.; Lind, L.; Lindgren, C.C.M.; Mannarino, E.; Mook-Kanamori, D.O.; Morris, A.P.; Mutsert, R. de; Rauramaa, R.; Saliba-Gustafsson, P.; Sennblad, B.; Smit, A.J.; Syvanen, A.C.; Tremoli, E.; Veglia, F.; Zethelius, B.; Bjorck, H.M.; Eriksson, J.G.; Hofman, A.; Franco, O.H.; Watkins, H.; Jukema, J.W. (0000-0002-3246-8359); Florez, J.C.; Wareham, N.J.; Meigs, J.B.; Ingelsson, E.; Baldassarre, D.; Hamsten, A.; IMPROVE Study Grp

ProinsulinAtherosclerosisIntima-media-thicknessSingle nucleotide polymorphismsGenetic variantsMendelian randomisation