Discovery and functional prioritization of Parkinson&#39;s disease candidate genes from large-scale whole exome sequencing

Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

Author(s):: Jansen, I.E.; Ye, H.; Heetveld, S.; Lechler, M.C.; Michels, H.; Seinstra, R.I.; Lubbe, S.J.; Drouet, V.; Lesage, S.; Majounie, E.; Gibbs, J.R.; Nalls, M.A.; Ryten, M.; Botia, J.A.; Vandrovcova, J.; Simon-Sanchez, J.; Castillo-Lizardo, M.; Rizzu, P.; Blauwendraat, C.; Chouhan, A.K.; Li, Y.R.; Yogi, P.; Amin, N.; Duijn, C.M. van; Morris, H.R.; Brice, A.; Singleton, A.B.; David, D.C.; Nollen, E.A.; Jain, S.; Shulman, J.M.; Heutink, P.; IPGDC

Parkinson's diseaseGenomicsWhole-exome sequencingLoss-of-functionRare variantsFunctional screeningMitochondriaParkinalpha-synucleinAnimal model