Immunotherapy in the Context of Hematopoietic Stem Cell Transplantation: The Emerging Role of Natural Killer Cells and Mesenchymal Stromal Cells

Author(s):
Lankester, A.C.; Ball, L.M.; Lang, P.; Handgretinger, R.
Published
2010
Publication type
Article / Letter to editor

Abstract

Immunotherapy in the context of hematopoietic stem cell transplantation has been dominated for many years by T-cell- and dendritic-cell-based treatment modalities. During the last decade, insight into the biology of natural killer (NK) cells and mesenchymal stromal cells (MSC) has rapidly increased and resulted in NK- and MSC-based therapeutic strategies in clinical practice. This article reviews current knowledge of the biology and clinical aspects of NK cells and MSC.

Immunotherapy Hematopoietic stem cell transplantation Natural killer cells Mesenchymal stromal cells versus-host-disease bone-marrow-transplantation umbilical-cord blood acute myeloid-leukemia inhibit lymphocyte-proliferation kir-ligand incompatibility breast-cancer patients suppress t-lymphocyte allogeneic nk cells class-i expression
Date issued
2010-02-28
Language
English
Is part of
Pediatric Clinics of North America (2010), Vol. 57, no. 1, p. 97
hdl
1887/111544