LXR beta deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp

Author(s):
Holm, S.; Voshol, P.J.; Gustafsson, J.A.; Nebb, H.I.
Published
2010
Publication type
Article / Letter to editor

Abstract

The present study addresses the insulin sensitivity in mice deficient in LXR beta (LXR beta(-/-)) as well as in wild type (wt) mice assessed by hyperinsulinemic euglycemic clamp Wt and LXR beta(-/-) mice were fed either a normal chow diet or a high fat and high cholesterol diet (HFCD), and Insulin sensitivity was assessed by hyperinsulinemic euglycemic clamps We show that LXR beta(-/-) mice have reduced insulin clearance during hyperinsulinemic clamps upon feeding both HFCD and a regular chow diet Moreover we also observed reduced hepatic inflammation in LXR beta(-/-) mice compared to wt mice upon feeding an HFCD, despite equal levels of hepatic steatosis. In summary, our results indicate that LXR beta(-/-) mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26 weeks (C) 2010 Elsevier Inc All rights reserved

Glucose Insulin Hepatic steatosis LXR Insulin clearance liver-x-receptor glucose metabolism alpha cholesterol inhibition accumulation sensitivity activation expression
Date issued
2010-02-12
Language
English
Is part of
Biochemical and Biophysical Research Communications (2010), Vol. 392, no. 3, p. 436-441
hdl
1887/110931