Cancer Immunotherapy: Will Expanding Knowledge Lead to Success in Pediatric Oncology?

Author(s):
Fry, T.J.; Lankester, A.C.
Published
2010
Publication type
Article / Letter to editor

Abstract

The past 25 years have seen an increase in our understanding of immunology and further expansion in the clinical use of immunotherapeutic modalities. How immunotherapy will be integrated with chemotherapy, radiation, and surgery remains to be established. Although there have been successes in the field of immunotherapy, they have been inconsistent, and it is hoped that increased understanding of the basic principles of immunology will improve the consistency of beneficial effects. In this article, we briefly provide a general overview of our current understanding of the immune system, with a focus on concepts in tumor immunology, followed by a discussion of how these concepts are being used in the clinic.

Cancer vaccines Adoptive cell transfer T cells NK cells B cells Tumor immunity stem-cell transplantation natural-killer-cells regulatory t-cells mhc class-i tumor-infiltrating lymphocytes acute lymphoblastic-leukemia acute myeloid-leukemia dendritic cells immune escape nk cells
Date issued
2010-02-28
Language
English
Is part of
Hematology/Oncology Clinics of North America (2010), Vol. 24, no. 1, p. 109
hdl
1887/110894