Impaired avidity maturation after tetanus toxoid booster in children with Down Syndrome

Author(s):
Kusters, M.A.; Jol-van der Zijde, C.M.; Tol, M.J. van; Bolz, W.E.; Bok, L.A.; Visser, M.; Vries, E. de
Published
2011
Publication type
Article / Letter to editor

Abstract

Down syndrome children show a decreased avidity of the antibody response after tetanus toxoid booster vaccination at 9 years of age suggesting impaired memory B cell selection in the germinal center. Clinicians need to be aware of this ongoing subtle immunologic deficit in Down syndrome.

Down syndrome tetanus toxoid antibody formation avidity children common variable immunodeficiency somatic hypermutation syndrome trisomy-21 antibody-response intrinsic defect antigens abnormalities deficiency cells
Date issued
2011-04-30
Language
English
Is part of
Pediatric Infectious Disease Journal (2011), Vol. 30, no. 4, p. 357-359
hdl
1887/110827