Pancytopenia due to proguanil toxicity in a returning traveller with fever

Author(s):
Jolink, H.; Hartigh, J. den; Visser, L.G. (0000-0002-3600-9782); Nieuwkoop, C. van
Published
2010
Publication type
Article / Letter to editor

Abstract

A patient known to have renal insufficiency was admitted to the hospital with fever and pancytopenia after returning from a trip to Mali. Pancytopenia was not caused by a tropical infection but was a side effect of atovaquone/proguanil used as malaria chemoprophylaxis. High and prolonged detectable proguanil serum levels can result in bone marrow suppression in patients with renal insufficiency. This should be taken into account in a returning traveller with fever and pancytopenia.

Pancytopenia Proguanil Malaria Chemoprophylaxis Renal insufficiency metabolism
Date issued
2010-08-31
Language
English
Is part of
European Journal of Clinical Pharmacology (2010), Vol. 66, no. 8, p. 811-812
hdl
1887/110674
doi
10.1007/s00228-010-0824-3