Pharmacogenetics of tomorrow: the 1+1=3 principle

Author(s):
Pander, J.; Wessels, J.A.M.; Mathijssen, R.H.J.; Gelderblom, H.; Guchelaar, H.J. (0000-0002-7085-1383)
Published
2010
Publication type
Article / Letter to editor

Abstract

Disappointing results from replicating pharmacogenetic association studies have prompted the search for novel statistical techniques to analyze the data, while taking into account the biological complexity underlying drug response. Two of these techniques multifactor dimensionality reduction and classification and regression tree analysis will probably be applied in increasing numbers of future pharmacogenetic studies. In this article, we describe the concepts underlying both techniques and illustrate their application in a recent pharmacogenetic study.

classification and regression tree multifactor dimensionality reduction pharmacogenetics sunitinib toxicity multifactor dimensionality reduction gene polymorphisms pathway analysis susceptibility cancer challenges epistasis toxicity impact
Date issued
2010-07-31
Language
English
Is part of
Pharmacogenomics (2010), Vol. 11, no. 7, p. 1011-1017
hdl
1887/110481
doi
10.2217/pgs.10.87