Evaluation of an MRI-based score of disease activity in perianal fistulizing Crohn's disease

Author(s):
Horsthuis, K.; Ziech, M.L.W.; Bipat, S.; Spijkerboer, A.M.; Bruine-Dobben, A.C. de; Hommes, D.W.; Stoker, J.
Published
2011
Publication type
Article / Letter to editor

Abstract

To evaluate a magnetic resonance imaging (MRI)-based score of disease severity for perianal fistulizing Crohn's disease (CD), 16 patients with perianal fistulizing CD underwent 1.5-T MRI before and after infliximab therapy. MRI scores, Perianal Disease Activity Index (PDAI) and C-reactive protein (CRP) were calculated, and fistula drainage was assessed. These items were compared for responders and nonresponders. After therapy, PDAI values and CRP values decreased significantly in responders, but there were no significant differences in the M RI scores. In all responders, MRI findings were indicative of persisting active inflammation. In these patients, a relapse rate of 57% was seen. (C) 2011 Elsevier Inc. All rights reserved.

Magnetic resonance imaging Crohn's disease Perianal fistula Inflammatory bowel disease infliximab treatment fistulas therapy ano
Date issued
2011-10-31
Language
English
Is part of
Clinical Imaging (2011), Vol. 35, no. 5, p. 360-365
hdl
1887/110474
doi
10.1016/j.clinimag.2010.09.003