Prospects of Magnetic Resonance Spectroscopy in Mouse Models of Alzheimer's Disease

Author(s):
Kara, F.; Braakman, N.; Buchem, M.A. van (0000-0003-1881-1998); Groot, H.J.M. de; Alia, A.
Published
2011
Publication type
Article / Letter to editor

Abstract

In vivo magnetic resonance spectroscopy is a powerful tool which can be applied non-invasively to monitor disease progression at a molecular level in the brain of human patients with Alzheimer's disease (AD) and transgenic mouse models of AD. Application of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in transgenic mouse models of AD makes it possible to follow metabolic changes and structural changes at the same time longitudinally. This review focuses on in vivo MRS studies in transgenic mouse models of AD and highlights the future impact of MRS techniques in finding crucial biomarkers of AD.

Alzheimer's Disease magnetic resonance spectroscopy transgenic mouse models mild cognitive impairment correlated mr spectroscopy brain in-vivo transgenic mice h-1 mrs neurodegenerative diseases h-1-nmr spectroscopy metabolism glutamate dementia
Date issued
2011-02-28
Language
English
Is part of
Current Medical Imaging Reviews (2011), Vol. 7, no. 1, p. 80-87
hdl
1887/110473
doi
10.2174/157340511794653469