The impact of margin status in breast-conserving therapy for lobular carcinoma is age related

Author(s):
Jobsen, J.J.; Riemersma, S.; Palen, J. van der; Ong, F.; Jonkman, A.; Struikmans, H.
Published
2010
Publication type
Article / Letter to editor

Abstract

Purpose: The aim is to look at the impact of margin status and outcome of invasive lobular carcinoma (ILC) treated with breast-conserving therapy (BCT). Methods: This manuscript describes an analysis on 330 BCT in 318 patients with ILC. Results: The 12-year local relapse free survival (LRFS) is 89%. In multivariate analysis, positive mar,gin status, age > 50 years. contra lateral breast cancer, and adjuvant systemic therapy were significant predictors of local relapse free survival. In a separate analysis limited to a positive margin for invasive carcinoma or carcinoma in situ, only a positive margin for invasive carcinoma was a significant predictor of local relapse free survival. This was limited to women < 50 years. The 12-year disease-specific survival (DSS) was 85%. In multivariate Cox regression analysis grade 3 compared to grade 2 (HR 7.2) and a tumour size of pT2 (HR 2.5) were significant independent predictors of disease-specific survival (DFS). These factors were also relevant for distant metastasis-free survival (DMFS) and disease-free survival (DFS). Conclusions: Positive margins for invasive carcinoma seem to be a strong predictor for local recurrence in particular for women <= 50-years. Our study showed grade 3 and tumour size to be strong predictors of DMFS, DFS. and DSS. Margin status was not. (C) 2009 Elsevier Ltd. All riahts reserved.

Breast-conserving therapy Lobular carcinomas Margin status Age Outcome 20-year follow-up local recurrence conservative surgery cancer mastectomy radiation outcomes trends trial risk
Date issued
2010-02-28
Language
English
Is part of
EJSO - European Journal of Surgical Oncology (2010), Vol. 36, no. 2, p. 176-181
hdl
1887/110468