Increased Carotid Intima-Media Thickness as a Predictor of the Presence and Extent of Abnormal Myocardial Perfusion in Type 2 Diabetes

Author(s):
Djaberi, R.; Schuijf, J.D.; Jukema, J.W. (0000-0002-3246-8359); Rabelink, T.J.; Stokkel, M.P.; Smit, J.W.; Koning, E.J. de; Bax, J.J.
Published
2010
Publication type
Article / Letter to editor

Abstract

OBJECTIVE - identification of asymptomatic patients with type 2 diabetes at increased risk for coronary artery disease (CAD) remains a challenge. We evaluated the Potential of carotid intima-media thickness (CIMT) for prediction of abnormal myocardial perfusion in this population. RESEARCH DESIGN AND METHODS- CIMT and SPECT myocardial perfusion imaging were assessed in 98 asymptomatic patients with type 2 diabetes. An increased CIMT was defined as >= 75th percentile of reference values. RESULTS - increased CIMT was an independent predictor of the extent of abnormal perfusion (P < 0.001). In patients with increased CIMT as compared with patients with normal CIMT, abnormal perfusion (75 vs. 9%) and severely abnormal perfusion (28 vs. 3%) were observed more frequently. CONCLUSIONS - increased CIMT was significantly related to the presence and extent of abnormal myocardial perfusion. Assessment of CIMT may be useful to identify asymptomatic patients with type 2 diabetes at higher risk for CAD.

ischemia mellitus disease diad risk
Date issued
2010-02-28
Language
English
Is part of
Diabetes Care (2010), Vol. 33, no. 2, p. 372-374
hdl
1887/110448
doi
10.2337/dc09-1301