Hematological characteristics in neonates with twin anemia-polycythemia sequence (TAPS)

Author(s):
Lopriore, E.; Slaghekke, F.; Oepkes, D.; Middeldorp, J.M.; Vandenbussche, F.P.H.A.; Walther, F.J.
Published
2010
Publication type
Article / Letter to editor

Abstract

Objective To evaluate the neonatal hematological features of monochorionic twins with twin anemia-polycythemia sequence (TAPS) and to determine the additional diagnostic value of reticulocyte Count Measurement. Methods A cohort of consecutive monochorionic twins with TAPS (n = 19) was included in the study and each twin pair was compared with two monochorionic twin pairs (n = 38) unaffected by TAPS or twin-twin transfusion syndrome (TTTS), matched for gestational age at birth. We measured full blood counts on day I and determined the incidence of anemia, polycythemia, reticulocytosis and thrombocytopenia. Results Median inter-twin hemoglobin (Hb) difference in monochorionic twins with and without TAPS was 13.7 g/dL and 2.4 g/dL, respectively (p < 0.01). Median inter-twin reticulocyte count ratio in twins with and without TAPS was 3.1 and 1.0. respectively (p < 0.01). Thrombocytopenia (platelet count < 150 x 10(9)/L) occurred more often in the TAPS group than in the control group, 45% (17/38) versus 11% (11/38), respectively (p < 0.01). In the TAPS group, mean platelet Count was significantly lower in recipients than in donors. 133 x 109/L versus 218 x 109/L, respectively (p < 0.01). Conclusions TAPS twins have a large inter-twin Hb difference in combination with a large inter-twin reticulocyte Count ratio. Recipients are more often thrombocytopenic than donors, probably Clue 10 polycythemia. Copyright (C) 2010 John Wiley & Sons, Ltd.

monochorionic twins twin anemia-polycythemia sequence twin-twin transfusion syndrome anemia polycythemia reticulocyte count thrombocytopenia chorionic-plate-anastomoses transfusion-syndrome monochorionic twins laser coagulation fetal complications
Date issued
2010-03-31
Language
English
Is part of
Prenatal Diagnosis (2010), Vol. 30, no. 3, p. 251-255
hdl
1887/110254