Power Doppler Area in the Diagnosis of Endometrial Cancer

Author(s):
Kroon, C.D. de; Hiemstra, E.; Trimbos, J.B.; Jansen, F.W. (0000-0002-5300-1694)
Published
2010
Publication type
Article / Letter to editor

Abstract

Objective: To evaluate the diagnostic accuracy of power Doppler area (PDA) in the detection of endometrial cancer in women with postmenopausal bleeding. Design: Prospective diagnostic study. Setting: University hospital. Population: Seventy-four consecutive women presenting with postmenopausal bleeding and a total endometrial thickness of more than 4 mm. Methods: The PDA was measured by pelvic ultrasound. Endometrial cancer and hyperplasia with complex atypia were considered abnormal. Main Outcome Measures: A receiver operating characteristic curve was constructed and area under curve (AUC) calculated as well as positive and negative likelihood ratios (LR+ and LR-). Results: Eighteen women (24%) had abnormal results of their histological specimen. The AUC of the PDA was 0.88(95% confidence interval [CI], 0.80-0.98). The LR+ and LR- of the PDA were, respectively, 14.5 (95% CI, 4.69-44.9) and 0.23 (95% CI, 0.09-0.55). In women with total endometrial thickness of 4 to 10 mm, the AUC, LR+, and LR- were, respectively, 0.91 (95% CI, 0.78-1.00), 23.9 (95% CI, 3.29-175.0), and 0.34 (95% CI, 0.13-0.86). Conclusions: The PDA is an effective measure in the diagnosis and exclusion of endometrial cancer.

Postmenopausal bleeding Endometrial cancer Gynecological ultrasound Power Doppler Diagnostics transvaginal color doppler women ultrasound carcinoma thickness benign ultrasonography metaanalysis accuracy
Date issued
2010-10-31
Language
English
Is part of
International Journal of Gynecological Cancer (2010), Vol. 20, no. 7, p. 1160-1165
hdl
1887/110040
doi
10.1111/IGC.0b013e3181f0df98