Transesophageal endoscopic ultrasound-guided fine-needle aspiration for the mediastinal staging of extrathoracic tumors: a new perspective

Author(s):
Peric, R.; Schuurbiers, O.C.J.; Veselic, M.; Rabe, K.F.; Heijden, H.F.M. van der; Annema, J.T.
Published
2010
Publication type
Article / Letter to editor

Abstract

Patients and methods: Consecutive patients with suspected mediastinal metastases (on computed tomography or positron emission tomography) and an (previous) extrathoracic malignancy underwent EUS-FNA. Results: Seventy-five patients with current (n = 14) or previously diagnosed (n = 61) extrathoracic malignancies were evaluated. EUS-FNA detected mediastinal malignancies in 43 patients (57%) [metastases of extrathoracic tumors, n = 36 (48%); second malignancy (lung cancer), n = 7 (9%)]. Mediastinal metastases were found at subsequent surgical staging in seven patients or during follow-up (one patient). In seven patients, an alternative diagnosis was established. Sensitivity, specificity, accuracy and negative predictive value of EUS-FNA for mediastinal staging were 86%, 100%, 91% and 72%, respectively. Conclusion: EUS-FNA is a minimally invasive mediastinal staging method for patients with extrathoracic malignancies to confirm nodal metastatic spread and therefore may qualify as an alternative for surgical staging.

ambulatory care endosonography extrathoracic cancer mediastinal disease cell lung-cancer breast-cancer eus-fna diagnosis
Date issued
2010-07-31
Language
English
Is part of
Annals of Oncology (2010), Vol. 21, no. 7, p. 1468-1471
hdl
1887/109983
doi
10.1093/annonc/mdp578